Contrasting R6, T6 and T3R3 Human Insulin

Highlighting the Less Exposed (Closed) and More Exposed (Open) Cavities for Zinc

R6 Insulin (Human)

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PDB structure: 1EVR; Smith, G.D., Ciszak, E.,
Magrum, L.A., Pangborn, W.A., Blessing, R. H.
(2000) Acta Crystallogr., Sect.D 56: 1541-1548

Insulin T6 (Human)

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PDB structure: 1MSO; Smith, G.D.,
Pangborn, W.A., Blessing, R. H.
(2003) Acta Crystallogr., D 59, 474-482
Crystallographic analysis yields pseudo-octahedral
Zn atoms each bound to 3 water molecules


Insulin T3R3 (Human)


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PDB Structure 1G7A:
Smith, G.D., Pangborn, W.A., Blessing, R.H.
2001, Acta Crystallogr.,Sect.D 57: 1091-1100