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1991 – 1993: Postdoctoral Fellow, Department of Chemistry and Chemical Biology; Harvard University, Cambridge, MA.
Research carried out in the laboratory of Professor Stuart L. Schreiber, involving the design and synthesis of analogs of cyclosporin A and their use as probes to study receptor-ligand interactions and cell signaling pathways.
1991: Ph.D. Organic Chemistry, University of California, Berkeley, CA
Thesis Title: "The Design, Synthesis, and Evaluation of Reaction Intermediate Analog Inhibitors of 5-Enolpyruvylshikimate-3-phosphate Synthase"Research was carried out in the group of Professor Paul A. Bartlett, in the Department of Chemistry.
1985: B.A. Chemistry, Carleton College, Northfield, MN.
David G. Alberg, Thomas B. Poulsen, Søren Bertelsen, Kasper L. Christensen, Rune D. Birkler, Mogens Johannsen, Karl Anker Jørgensen, "Organocatalysis with Endogenous Compounds: Towards Novel Non-enzymatic Reactions", Bioorg. Med. Chem. Lett., 2009, 19, 3888-3891.
Funke, T.; Healy-Fried, M. L., Han, H.; Alberg, D. G.; Bartlett, P. A; Schönbrunn, E., “Differential Inhibition of Class I and Class II 5-Enolpyruvylshikimate-3-phosphate Synthases by Tetrahedral Reaction Intermediate Analogues”, Biochemistry, 2007, 46, 13344-13351.
Czechowicz, J. A.; Wilhelm, A. K.; Spalding, M. D.; Larson, A. M.; Engel, L. K.; Alberg, D. G, “The Synthesis and Inhibitory Activity of Dethiotrypanothione and Analogues against Trypanothione Reductase”, J. Org. Chem., 2007, 72, 3689-3693.
Jerry R. Mohrig, David G. Alberg, Craig H. Cartwright, Mary Kay H. Pflum, Jeffrey S. Aldrich, J. Kyle Anderson, Shelby R. Anderson, Ryan L. Fimmen, Amy K. Snover, "Stereochemistry of 1,2-Elimination Reactions at the E2-E1cB Interface–tert-Butyl 3-Tosyloxybutanoate and its Thioester", Org. and Biomol. Chem., 2008, 6, 1641-1646.
Priestman, M. A.; Healy, M. L.; Becker, A.; Alberg, D. G.; Bartlett, P. A.; Lushington, G. H.; Schonbrunn, E. “Interaction of Phosphonate Analogues of the Tetrahedral Reaction Intermediate with 5-Enolpyruvylshikimate-3-phosphate Synthase in Atomic Detail,” Biochemistry, 2005; 44; 3241-3248.
Elizabeth A. Garrard, Emily C. Borman, Brian N. Cook, Emily J. Pike, David
G. Alberg; "Inhibition of
Trypanothione Reductase by Substrate Analogues", Organic Letters,
2000, 2, 3639-3642.
Peter J. Belshaw, Stephanie D. Meyer, Donna D. Johnson, Daniel Romo, Yoshihara Ikeda, Merritt Andrus, David G. Alberg, L. Wayne Schultz, Jon Clardy, Stuart L. Schreiber, "Synthesis, Structure and Mechanism in Immunophilin Research", SynLett 1994, 381-392.
Hengming Ke, Dale Mayrose, Peter J. Belshaw, David G. Alberg, Stuart L. Schreiber, Zhi Yuh Chang, Felecia A. Etzkorn, Susanna Ho and Christoper T. Walsh, "Crystal Structures of Cyclophilin A Complexed with Cyclosporin A and N-Methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine Cyclosporin A" Structure, 1994, 2, 33-44.
David G. Alberg and Stuart L. Schreiber, "Structure-Based Design of a Cyclophilin-Calcineurin Bridging Ligand", Science, 1993 262, 248-250.
Teresa Lyson, LeAnn D. Ermel, Peter J. Belshaw, David G. Alberg, Stuart L. Schreiber, and Ronald G. Victor, "Calcineurin as a Common Target Mediating Cyclosporin A and FK506 Induced Sympathetic Activation and Acute Hypertension" Circulation Research., 1993, 73, 596-602.
Michael K. Rosen, Peter J. Belshaw, David G. Alberg, Stuart L. Schreiber, "The Conformation of Cyclosporin A Bound to Cyclophilin is Altered (Once Again) Following Binding to Calcineurin: an Analysis of Receptor-Ligand-Receptor Interactions," Bioorg. Med. Chem. Lett., 1992, 2, 747-751.
J. Liu, M. W. Albers, T. J. Wandless, S. Luan, D. G. Alberg, P. J. Belshaw, P. Cohen, C. MacKintosh, C. B. Klee, and S. L. Schreiber, "Inhibition of T Cell Signaling By Immunophilin-Ligand Complexes Correlates with Loss of Calcineurin Phosphatase Activity," Biochemistry, 1992, 31, 3896-3901.
David G. Alberg, Charles T. Lauhon, Robert Nyfeler, Alex Fässler, and Paul A. Bartlett, "Inhibition of EPSP Synthase by Analogues of the Tetrahedral Intermediate and of EPSP," J. Am. Chem. Soc., 1992, 114, 3535-3546.
Paul A. Bartlett, Kevin. L. McLaren, David G. Alberg, Alex Fässler, Robert Nyfeler, Charles T. Lauhon, and Charles B. Grissom, "Exploration of the Shikimic Acid Pathway: Opportunities for the Study of Enzyme Mechanisms through the Synthesis of Intermediates and Inhibitors," in Prospects for Amino Acid Biosynthesis Inhibitors in Crop Protection andPharmaceutical Chemistry, L. G. Copping, Editor, Society of Chemical Industry; 1989, 155-170.
David G. Alberg and Paul A. Bartlett, "Potent Inhibition of 5-Enolpyruvylshikimate-3-phosphate Synthase by a Reaction Intermediate Analog," J. Am. Chem. Soc., 1989, 111, 2337-2338.
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